Publikationen des Sonderforschungsbereiches 900

SFB 900 – Publikationen

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Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals. Behrens GMN, Cossmann A, Stankov MV, Schulte B, Streeck H, Förster R, Bosnjak B, Willenzon S, Boeck A-L, Tran AT, Thiele T, Graalmann T, Kayser MZ, Zychlinsky Scharff A, Dopfer C, Horke A, Pink I, Witte T, Wetzke M, Ernst D, Jablonka A, Happle S. Infect Dis Ther. 2020 Dec ;9(4):837-849.

Why? – Successful Pseudomonas aeruginosa clones with a focus on clone C. Lee C, Klockgether J, Fischer S, Trcek J, Tümmler B, Römling U. FEMS Microbiology Reviews 2020 Nov Volume 44, Issue 6, November 2020, Pages 740–762

Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Brown RJP, Tegtmeyer B, Sheldon J,Khera T Anggakusuma, Todt D, Vieyres D, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C,Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR, Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Dao Thi VL, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. Sci Adv. 2020 Nov ; 6(45): eabd3233.

Brd/BET Proteins Influence the Genome-Wide Localization of the Kaposi’s Sarcoma-Associated Herpesvirus and Murine Gammaherpesvirus Major Latency Proteins. Lotke R, Schneeweiß U, Pietrek M ,Günther T , Grundhoff A, Weidner-Glunde M, Schulz TF. Front Microbiol. 2020 Oct 22 ; 11:591778.

Disturbed gut microbiota and bile homeostasis in Giardia-infected mice contributes to metabolic dysregulation and growth impairment. Riba A, Hassani K, Walker A, van Best N, von Zeschwitz D, Anslinger T, Sillner N, Rosenhain S, Eibach D, Maiga-Ascofaré O, Rolle-Kampczyk U, Basic M, Binz A, Mocek A, Sodeik B, Bauerfeind R, Mohs A, Trautwein C, Kiessling F, May J, Klingenspor M, Gremse F, Schmitt-Kopplin P, Bleich A, Torow N, von Bergen M, Hornef MW. Sci Transl Med. 2020 Oct 14 ;12(565):eaay7019.

Quantitative Proteomics Analysis of Lytic KSHV Infection in Human Endothelial Cells Reveals Targets of Viral Immune Modulation. Gabaev I, Williamson JC, Crozier TWN, Schulz TF, Lehner PJ. Cell Rep. 2020 Oct 13;33(2):108249.

Reversal of Immunity After Clearance of Chronic HCV Infection—All Reset? Wedemeyer H, Khera T, Strunz B, Björkström NK. Front Immunol. 2020 Oct 8 ; 11: 571166.

CAR-T cells and TRUCKs that recognize an EBNA-3C-derived epitope presented on HLA-B*35 control Epstein-Barr virus-associated lymphoproliferation. Dragon AC, Zimmermann K, Nerreter T, Sandfort D, Lahrberg J, Klöß S, Kloth C, Mangare C, Bonifacius A, Tischer-Zimmermann S, Blasczyk R, Maecker-Kolhoff B, Uchanska-Ziegler B, Abken H, Schambach A, Hudecek M, Eiz-Vesper B. J Immunother Cancer. 2020 Oct ;8(2):e000736.

Murine Cytomegalovirus M25 Proteins Sequester the Tumor Suppressor Protein p53 in Nuclear Accumulations. Kutle I, Szymańska-de Wijs KM, Bogdanow B, Cuvalo B, Steinbrück L, Jonjić S, Wagner K, Niedenthal R, Selbach M, Wiebusch L, Dezeljin M*, Messerle M*. *Contributed equally. J Virol. 2020 Sep 29;94(20):e00574-20.

Herpes Simplex Virus Type 2 Counteracts Neurite Outgrowth Repulsion During Infection In A Nerve Growth Factor-Dependent Manner. Kropp KA, López-Muñoz AD , Ritter B, Martín R, Rastrojo A, Srivaratharajan S, Döhner K, Dhingra A, Czechowicz JS, Nagel CH, Sodeik B, Alcami A, Viejo-Borbolla A. J Virol. 2020 Sep 29;94(20):e01370-20.

Molecular epidemiology in current times. Schwanke H, Stempel M, Brinkmann MM. Environmental Microbiology.2020 Sep 17 Minireview.

HCV Glycoprotein Structure and Implications for B-Cell Vaccine Development. Ströh L, Krey T. Int J Mol Sci. 2020 Sep 16;21(18):E6781.

Hit-to-lead optimization of a latency-associated nuclear antigen inhibitor against Kaposi’s sarcoma-associated herpesvirus infections. Kirsch P, Stein SC, Berwanger A, Rinkes J, Jakob V, Schulz TF, Empting M. Eur J Med Chem. 2020 Sep 15 ;202:112525.

Cholesterol sensing by CD81 is important for hepatitis C virus entry. Palor M., Stejskal L, Mandal P, Lenman A, Alberione MP, Kirui J, Moeller R, Ebner S, Meissner F, Gerold G, Shepherd AJ, Grove J. J Biol Chem. 2020 Sep 8 ;jbc.RA120.014761.

Evolved to vary: genome and epigenome variation in the human pathogen Helicobacter pylori. Ailloud F, Estibariz I, Suerbaum S. FEMS Microbiology Reviews 2020 Sep 03 fuaa042

Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus. Carpentier A, Sheldon J, Vondran JWR, Brown RJP, Pietschmann T. Gut. 2020 Sep ;69(9):1659-1666.

The burden of hepatitis D – defogging the epidemiological horizon. Wedemeyer H. Journal of Hepatology 2020 Sep Volume 73, Issue 3, Pages 493-495; Editorial

Global and local envelope protein dynamics of hepatitis C virus determine broad antibody sensitivity. Augestad EH, Castelli M, Clementi N, Ströh LJ, Krey T, Burioni R, Mancini N,Bukh J, Prentoe J. Sci Adv. 2020 Aug 26 ;6(35):eabb5938.

In Vivo Genome and Methylome Adaptation of cag-Negative Helicobacter pylori during Experimental Human Infection. Estibariz I, Ailloud F, Woltemate S, Bunk B, Spröer C, Overmann J, Aebischer T, Meyer TF, Josenhans C, Suerbaum S. mBio. 2020 Aug 25;11(4):e01803-20.

Absence of cGAS-mediated type I IFN responses in HIV-1-infected T cells. Elsner C, Ponnurangam A, Kazmierski J, Zillinger T, Jansen J, Todt D, Döhner K, Xu S, Ducroux A, Kriedemann N, Malassa A, Larsen P-K, Hartmann G, Barchet W, Steinmann E, Kalinke U, Sodeik B, Goffinet C. Proc Natl Acad Sci U S A. 2020 Aug 11 ;117(32):19475-19486.

Combating COVID-19: MVA Vector Vaccines Applied to the Respiratory Tract as Promising Approach Toward Protective Immunity in the Lung. Förster R, Fleige H, Sutter G. Front Immunol. 2020 Aug 7 ;11: 1959.

Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D, Prinz I. Proc Natl Acad Sci U S A. 2020 Aug 4 ;117(31):18649-18660.

Reappearance of Effector 1 T Cells Is Associated With Recovery from COVID-19. Odak I, Barros-Martins J,Bošnjak B,Stahl K,David S, Wiesner O, Busch M, Hoeper MM,Pink I, Welte T, Cornberg M, Stoll M, Goudeva L, Blasczyk R, Ganser A, Prinz I, Förster R, Koenecke C*, Schultze-Florey CR.* *Authors contributed equally. EBioMedicine. 2020 Jul ;57:102885.

Of Keeping and Tipping the Balance: Host Regulation and Viral Modulation of IRF3-Dependent IFNB1 Expression. Schwanke H, Stempel M, Brinkmann MM. Viruses. 2020 Jul 7 ;12(7):733.

Whole-Genome Approach to Assessing Human Cytomegalovirus Dynamics in Transplant Patients Undergoing Antiviral Therapy. Suárez NM, Blyth E, Li K, Ganzenmueller T, Camiolo S, Avdic S, Withers B, Linnenweber-Held S, Gwinner W, Dhingra A, Heim A, Schulz TF, Gunson R, Gottlieb D, Slobedman B, Davison AJ. Front Cell Infect Microbiol. 2020 Jun 15 ;10:267.

The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. Vieyres G, Reichert I, Carpentier A, Vondran FWR, Pietschmann T. PLoS Pathog. 2020 Jun ; 16(6): e1008554.

The Cytomegalovirus Tegument Protein UL35 Antagonizes Pattern Recognition Receptor-Mediated Type I IFN Transcription. Fabits M, Gonçalves Magalhães V, Chan B, Girault V, Elbasani E, Rossetti E, Saeland E, Messerle M, Pichlmair A, Lisnić VJ, Brinkmann MM. Microorganisms. 2020 May 26;8(6):E790.

Proteoglycan-dependent endo-lysosomal fusion affects intracellular survival of Salmonella Typhimurium in epithelial cells. Galeev A, Suwandi A, Bakker H, Oktiviyari A, Routier FH, Krone L, Hensel M, Grassl GA. Front Immunol. 2020 Apr 29;11:731.

Single-nucleotide variants in human CD81 influence hepatitis C virus infection of hepatoma cells. Alberione MP, Moeller R, Kirui J, Ginkel C, Doepke M, Ströh LJ, Machtens JP, Pietschmann T, Gerold G. Med Microbiol Immunol. 2020 Apr 22 : 1–16

Donor-derived IL-17A and IL-17F deficiency triggers Th1 allo-responses and increases gut leakage during acute GVHD. Odak I, Depkat-Jakob, A, Beck M, Jarek M, Yu Y, Seidler U, David S, Ganser A, Förster R, Prinz I, Koenecke C. PLoS One. 2020 Apr 6 ;15(4):e0231222.

Human γδ TCR Repertoires in Health and Disease. Fichtner AS, Ravens S, Prinz I. Cells 2020 Mar 26;9(4):E800.

Revisiting the Interaction of γδ T-Cells and B-Cells. Rampoldi, F, Ullrich L, Prinz I. Cells. 2020 Mar; 9(3): 743.

Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance. Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle O, Halle S, Patzer GE, Bošnjak B, Kiefer F, Janssen A, Friedrichsen M, Poetzsch J, Kohli K, Lueder Y, Gutierrez Jauregui R, Eckert N, Worbs T, Galla M, Förster R. Nat Commun. 2020 Feb 28 ;11(1):1114.

Discovery of Novel Latency-Associated Nuclear Antigen Inhibitors as Antiviral Agents Against Kaposi’s Sarcoma-Associated Herpesvirus. Kirsch P, Jakob V, Elgaher WAM, Walt C ,Oberhausen K, Schulz TF, Empting M. ACS Chem Biol . 2020 Feb 21 ;15(2):388-395.

TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. J Leukoc Biol. 2020 Feb 17

One Step Ahead: Herpesviruses Light the Way to Understanding Interferon-Stimulated Genes (ISGs). Gonzalez-Perez AC, Stempel M, Chan B, Brinkmann MM. Front Microbiol. 2020 Feb 7 ;11:124.

The deubiquitinase OTUB1 augments NF-κB-dependent immune responses in dendritic cells in infection and inflammation by stabilizing UBC13. Mulas F, Wang X, Song S, Nishanth G, Yi W, Brunn A, Larsen PK, Isermann B, Kalinke U, Barragan A, Naumann M, Deckert M, Schlüter D. Cell. Mol. Immunol.2020 February 05

Intraclonal competitive fitness of longitudinal cystic fibrosis Pseudomonas aeruginosa airway isolates in liquid cultures. Cramer N, Fischer S, Hedtfeld S, Dorda M, Tümmler B. Environmental Microbiology 2020 Jan 26

B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2019 Dec 16

Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft-versus-host disease. Odak I, Raha S, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I, Koenecke C. Haematologica December 2019 104: e577-e580

Characterization of Endogenous SERINC5 Protein as Anti-HIV-1 Factor. Passos V, Zillinger T, Casartelli N, Wachs AS, Xu S, Malassa A, Steppich K, Schilling H, Franz S, Todt D, Steinmann E, Sutter K, Dittmer U, Bohne J, Schwartz O, Barchet W, Goffinet C. J Virol 2019 Dec; 93;24

Quantitative proteomics of Uukuniemi virus – host cell interactions reveals GBF1 as proviral host factor for phleboviruses. Uckeley ZM*, Moeller R*, Kühn LI, Nilsson E, Robens C, Lasswitz L, Lindqvist R, Lenman A, Passos V, Voß Y, Sommerauer C, Kampmann M, Goffinet C, Meissner F, Överby AK, Lozach PY, Gerold G. Mol. Cell. Proteomics 2019 September 30 *This authors contributed equally.

STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Tegtmeyer PK, Spanier J, Borst K, Becker J, Riedl A, Hirche C, Ghita L, Skerra J, Baumann K, Lienenklaus S, Doering M, Ruzsics Z, Kalinke U. Nat Commun. 2019 Jun 27;10(1):2830.

Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S. Cell Rep. 2019 Jun 18; 27(12):3657-3671.e4.

Persistent Salmonella enterica serovar Typhimurium infection induces protease expression during intestinal fibrosis. Erhardt K, Steck N, Kappelhoff R, Stein S, Rieder F, Gordon IO, Boyle EC, Braubach P, Overall CM, Finlay BB, Grassl GA. Inflamm Bowel Dis. 2019 May 9

Kaposi’s sarcoma-associated herpesvirus vIRF2 protein utilizes an IFN-dependent pathway to regulate viral early gene Expression. Koch S, Damas M, Freise M, Hage E, Dhingra A, Rückert J, Gallo A, Kremmer E, Tegge W, Brönstrup M, Brune W, Schulz TF. PLOS Pathogens May 6, 2019; 49(5):686-693

Styk1 is speciffically expressed in NK1.1 + lymphocytes including NK, γδ, and iNKT cells in mice, but is dispensable for their ontogeny and function. Wilharm A, Sandrock I, Marotel M, Demera A, Naumann R, Walzer T, Primz I. Eur J Immunol. 2019 May;49(5):686-693

Within-host evolution of Helicobacter pylori shaped by niche-specific adaptation, intragastric migrations and selective sweeps. Ailloud F, Didelot X, Woltemate S, Pfaffinger G, Overmann J, Bader R C, Schulz C, Malfertheiner P, Suerbaum S. Nat Commun. 2019 May 22;10(1):2273

Cytomegalovirus memory inflation and immune protection. Cicin-Sain, L. Med Microbiol Immunol 2019 April 10 208, 339–347

Robust Identification of Suitable T-Cell Subsets for Personalized CMV-Specific T-Cell Immunotherapy Using CD45RA and CD62L Microbeads. Mangare C, Tischer-Zimmermann S,Riese SB, Dragon AC , Prinz I,Blasczyk R, Maecker-Kolhoff B, Eiz-Vesper B. Int. J. Mol. Sci. 2019 March 19; 20,1415

The core genome m5C methyltransferase JHP1050 (M.Hpy99III) plays an important role in orchestrating gene expression in Helicobacter pylori. Estibariz I, Overmann A, Ailloud F, Krebes J, Josenhans C, Suerbaum S Nucleic Acids Res. 2019 Mar 18 47(5):2336-2348

HCV Pit Stop at the Lipid Droplet: Refuel Lipids and Put on a Lipoprotein Coat before Exit. Vieyres G, Pietschmann T Cells. 2019 Mar 12;8(3) pii: E233

Mutual interplay between IL-17-producing γδT cells and microbiota orchestrates oral mucosal homeostasis. Wilharm A, Tabib Y, Nassar M, Reinhardt A, Mizraji G, Sandrock I, Heyman O, Barros-Martins J, Aizenbud Y, Khalaileh A, Eli-Berchoer L, Elinav E, Wilensky A, Förster R, Bercovier H, Prinz I, Hovav AH Proc Natl Acad Sci U S A. 2019 Feb 12 116(7):2652-2661

The endosomal Toll-like receptor 7 and 9 cooperate in detection of MHV68 infection. Bussey KA, Murthy S, Reimer E, Chan B, Hatesuer B, Schughart K, Glauinger B, Adler H, Brinkmann MM J Virol. 2019 Jan 17;93(3). pii: e01173-18.

Genetic models reveal origin, persistence and non-redundant functions of IL-17–producing γδ T cells. Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I J Exp Med. 2018 Nov 19. pii: jem.20181439

Schistosome eggs impair protective Th1/Th17 Immune Responses against Salmonella infection. Schamm G, Suwandi A, Galeev A, Sharma S, Braun J, Claes AK, Grassl GA Front Immunol. 2018 Nov 14;9:2614.

SIVcol Nef counteracts SERINC5 by promoting its proteasomal degradation but does not efficiently enhance HIV-1 replication in human CD4+ T cells and lymphoid tissue. Kmiec D, Akbil B, Ananth S, Hotter D, Sparrer KMJ, Stürzel CM, Trautz B, Ayouba A, Peeters M, Yao Z, Stagljar I, Passos V, Zillinger T, Goffinet C, Sauter D, Fackler OT, Kirchhoff F. PLoS Pathog. 2018 Aug 20;14(8):e1007269.

Hepatitis C virus enters liver cells using the CD81 receptor complex proteins calpain-5 and CBLB. Bruening J, Lasswitz L, Banse P, Kahl S, Marinach C, Vondran FW, Kaderali L, Silvie O, Pietschmann T, Meissner F, Gerold G. PLoS Pathog. 2018 Jul 19;14(7):e1007111.

Control of primary mouse cytomegalovirus infection in lung nodular inflammatory 1 foci by cooperation of Interferon-gamma expressing CD4 and CD8 T cells. Lueder Y, Heller K, Ritter C, Keyser KA, Wagner K, Liu X, Messerle M, Stahl FR, Halle S, Förster R Plos Pathog. 2018 Aug 28;14(8):e1007252.

Conformational flexibility in the CD81 binding 1 site of the HCV glycoprotein E2. Ströh LJ, Nagarathinam K, Krey T Front Immunol. 2018 Jun 18; 9:1396.

The Antiviral Activity of the Cellular Glycoprotein LGALS3BP/90K is Species-Specific. Lodermeyer V, Ssebyatika G, Passos V, Ponnurangam A, Malassa A, Ewald E, Stürzel CM, Kirchhoff F, Rotger M, Falk CS, Telenti A, Krey T, Goffinet C J Virol. 2018 May 9; pii: JVI.00226-18.

De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Stüve P, Minarrieta L, Erdmann H, Arnold-Schrauf C, Swallow M, Guderian M, Krull F, Hölscher A, Ghorbani P, Behrends J, Abraham WR, Hölscher C, Sparwasser TD, Berod L Front Immunol. 2018 Apr 5;9:495.

The interferon-stimulated gene product oligoadenylate synthetase-like protein enhances replication of Kaposi’s sarcoma-associated herpesvirus (KSHV) and interacts with the KSHV ORF20 protein. Bussey KA, Lau U, Schumann S, Gallo A, Osbelt L, Stempel M, Arnold C, Wissing J, Gad HH, Hartmann R, Brune W, Jänsch L, Whitehouse A, Brinkmann MM PLoS Pathog. 2018 Mar 2;14(3):e1006937

Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Ravens S, Hengst J, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H, Prinz I Front Immunol. 2018 Mar 16;9:510.

Targeting Mycobacterium tuberculosis Antigens to Dendritic Cells via the DC-Specific-ICAM3-Grabbing-Nonintegrin Receptor Induces Strong T-Helper 1 Immune Responses. Velasquez LN, Stüve P, Gentilini MV, Swallow M, Bartel J, Lycke NY, Barkan D, Martina M, Lujan HD, Kalay H, van Kooyk Y, Sparwasser TD, Berod L Front Immunol. 2018 Mar 9;9:471.

Long-term Microevolution of Pseudomonas aeruginosa Differs Between Mildly and Severely Affected Cystic Fibrosis Lungs. KlockgetherJ, Cramer N, Fischer S, Wiehlmann L, Tümmler B  Am J Respir Cell Mol Biol. 2018 Feb 22.

Genome and Methylome Variation in Helicobacter pylori With a cag Pathogenicity Island During Early Stages of Human Infection.Nell S, Estibariz I, Krebes J, Bunk B, Graham DY, Overmann J, Song Y, Spröer C, Yang I, Wex T, Korlach J, Malfertheiner P, Suerbaum S Gastroenterology. 2018 Feb; 154(3):612-623.

Importin α1 is required for nuclear import of herpes simplex virus proteins and capsid assembly in fibroblasts and neurons. Döhner K, Ramos-Nascimento A, Bialy D, Anderson F, Hickford-Martinez A, Rother F, Koithan T, Rudolph K, Buch A, Prank U, Binz A, Hügel S, Lebbink RJ, Hoeben RC, Hartmann E, Bader M, Bauerfeind R, Sodeik B PLoS Pathog. 2018 Jan 5;14(1):e1006823.

Inner tegument proteins of Herpes Simplex Virus are sufficient for intracellular capsid motility in neurons but not for axonal targeting. Buch A, Müller O, Ivanova L, Döhner K, Bialy D, Bosse JB, Pohlmann A, Binz A, Hegemann M, Nagel CH, Koltzenburg M, Viejo-Borbolla A, Rosenhahn B, Bauerfeind R, Sodeik B. PLoS Pathog. 2017 Dec 28;13(12):e1006813.

Myeloid dendritic cells repress human cytomegalovirus gene expression and spread by releasing interferon-unrelated soluble antiviral factors. Kasmapour B, Kubsch T, Rand U, Eiz-Vesper B, Messerle M, Vondran FWR, Wiegmann B, Haverich A, Cicin-Sain L. J Virol. 2017 Dec 14;92(1).

The M25 gene products are critical for the cytopathic effect of mouse cytomegalovirus. Kutle I, Sengstake S, Templin C, Glaß M, Kubsch T, Keyser KA, Binz A, Bauerfeind R, Sodeik B, Čičin-Šain L, Dezeljin M, Messerle M. Sci Rep. 2017 Nov 14;7(1):15588.

Genome and Methylome Variation in Helicobacter pylori With a cag Pathogenicity Island During Early Stages of Human Infection. Nell S, Estibariz I, Krebes J, Bunk B, Graham DY, Overmann J, Song Y, Spröer C, Yang I, Wex T, Korlach J, Malfertheiner P, Suerbaum S. Gastroenterology. 2017 Oct 21. pii: S0016-5085(17)36273-X

Characterization of high-avidity CMV specific T-cells with differential tetramer binding co-appearing after allogeneic SCT. Ogonek J, Verma K, Schultze-Florey S, Varanasi P, Luther S, Schweier P, Kühnau W, Göhring G, Dammann E, Stadler M, Ganser A, Koehl U,  Koenecke C, Weissinger EM, Hambach L. J Immunol. 2017 Jul 15;199(2):792-805.

Helicobacter pylori modulates host cell responses by CagT4SS-dependent translocation of an intermediate metabolite of LPS inner core heptose biosynthesis. Stein SC, Faber E, Bats SH, Murillo T, Speidel Y, Coombs N, Josenhans C. PLoS Pathog. 2017 Jul 17;13(7):e1006514.

Lactate oxidation facilitates growth of Mycobacterium tuberculosis in human macrophage. Sci Rep. 2017 Jul 25;7(1):6484.

Recent advances in understanding of Pseudomonas aeruginosa as a pathogen. F1000Res. 2017 Jul 28;6:1261.

Kaposi’s Sarcoma Herpesvirus Latency-Associated Nuclear Antigen (LANA): Replicating and Shielding Viral DNA during Viral Persistence. Weidner-Glunde M, Mariggiò G, Schulz TF. J Virol. 2017 Jun 26;91(14). pii: e01083-16.

Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells. Lino CNR, Barros-Martins J, Oberdörfer L, Walzer T, Prinz I. Eur J Immunol. 2017 Jun;47(6):970-981.

Cell Polarization and Epigenetic Status Shape the Heterogeneous Response to Type III Interferons in Intestinal Epithelial Cells. Bhushal S, Wolfsmüller M, Selvakumar T, Kemper L, Wirth D, Hornef MW, Hauser H, Köster M. Front Immunol. 2017 Jun 12;8:671. d

Hepatitis C virus strain-dependent usage of apolipoprotein E modulates assembly efficiency and specific inactivity of secreted virions. Weller R, Hueging K, Brown RJP, Todt D, Joecks S, Vondran FWR, Pietschmann T. J Virol. 2017 Jun 28. pii: JVI.00422-17.

A screening assay for the identification of host cell requirements and antiviral targets for hepatitis D virus infection. Buchmann B, Döhner K, Schirdewahn T, Sodeik B, Manns MP, Wedemeyer H, Ciesek S, von Hahn T. Antiviral Res. 2017 May;141:116-123.

Vertex-Specific Proteins pUL17 and pUL25 Mechanically Reinforce Herpes Simplex Virus Capsids. Snijder J, Radtke K, Anderson F, Scholtes L, Corradini E, Baines J, Heck AJR, Wuite GJL, Sodeik B, Roos WH. J Virol. 2017 May 26;91(12). pii: e00123-17.

Varicella zoster virus glycoprotein C increases chemokine-mediated leukocyte migration. González-Motos V, Jürgens C,  Ritter B, Kropp K, Durán V, Larsen O, Binz A,Ouwendijk W, Lenac Rovis T, Jonjic S, Verjans G, Sodeik B, Krey T, Bauerfeind R, Schulz TF, Kaufer BB, Kalinke U, Proudfoot A, Rosenkilde MM and Viejo-Borbolla A. PLoS Pathog. 2017 May 25;13(5):e1006346.

The murine cytomegalovirus M35 protein antagonizes type I IFN induction downstream of pattern recognition receptors by targeting NF-κB mediated transcription. Chan B, Gonçalves Magalhães V, Lemmermann NAW, Juranić Lisnić V, Stempel M, Bussey KA, Reimer E, Podlech J, Lienenklaus S, Reddehase MJ, Jonjić S, Brinkmann MM. PLoS Pathog. 2017 May 25;13(5):e1006382.

Repulsive behavior in germinal centers. Moschovakis GL, Förster R. Science. 2017 May 19;356(6339):703-704.

Conformational flexibility in the immunoglobulin-like domain of the Hepatitis C Virus Glykoprotein E2. Vasiliauskaite I, Owsianka A, England P, Khan AG, Cole S, Bankwitz D, Foung SKH, Pietschmann T, Marcotrigiano J, Rey FA, Patel AH, Krey T. MBio. 2017 May 16;8(3). pii: e00382-17.

Kaposi Sarcoma Herpesvirus (KSHV) Latency-Associated Nuclear Antigen (LANA) recruits components of the MRN (Mre11-Rad50-NBS1) repair complex to modulate an innate immune signaling pathway and viral latency. Mariggiò G, Koch S, Zhang G, Weidner-Glunde M, Rückert J, Kati S, Santag S, Schulz TF. PLoS Pathog. 2017 Apr 21;13(4):e1006335.

Human gd T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C, Prinz I. Nat Immunol. 2017 Apr;18(4):393-401.

Maturation of secreted HCV particles by incorporation of secreted apoE protects from antibodies by enhancing infectivity. Bankwitz D, Doepke M, Hueging K, Weller R, Bruening J, Behrendt P, Lee JY, Vondran FWR, Manns MP, Bartenschlager R, Pietschmann T. J Hepatol. 2017 Apr 21. pii: S0168-8278(17)30251-9.

Scavenger receptor class B member 1 (SCARB1) variants modulate hepatitis C virus replication cycle and viral load. Westhaus S, Deest M, Nguyen ATX, Stanke F, Heckl D, Costa R, Schambach A, Manns MP, Berg T, Vondran FWR, Sarrazin C, Ciesek S, von Hahn T. J Hepatol. 2017 Mar 29. pii: S0168-8278(17)30184-8.

Characterization of human cytomegalovirus genome diversity in immunocompromised hosts by whole genomic sequencing directly from clinical specimens. Hage E, Wilkie GS, Linnenweber-Held S, Dhingra A, Suárez NM, Schmidt JJ, Kay-Fedorov P, Mischak-Weissinger E, Heim A, Schwarz A, Schulz TF, Davison AJ, Ganzenmueller T. J Infect Dis. 2017 Mar 27.

Helicobacter pylori Adapts to Chronic Infection and Gastric Disease via pH-Responsive BabA-Mediated Adherence. Bugaytsova JA, Björnham O, Chernov YA, Gideonsson P, Henriksson S, Mendez M, Sjöström R, Mahdavi J, Shevtsova A, Ilver D, Moonens K, Quintana-Hayashi MP, Moskalenko R, Aisenbrey C, Bylund G, Schmidt A, Åberg A, Brännström K, Königer V, Vikström S, Rakhimova L, Hofer A, Ögren J, Liu H, Goldman MD, Whitmire JM, Ådén J, Younson J, Kelly CG, Gilman RH, Chowdhury A, Mukhopadhyay AK, Nair GB, Papadakos KS, Martinez-Gonzalez B, Sgouras DN, Engstrand L, Unemo M, Danielsson D, Suerbaum S, Oscarson S, Morozova-Roche LA, Olofsson A, Gröbner G, Holgersson J, Esberg A, Strömberg N, Landström M, Eldridge AM, Chromy BA, Hansen LM, Solnick JV, Lindén SK, Haas R, Dubois A, Merrell DS, Schedin S, Remaut H, Arnqvist A, Berg DE, Borén T. Cell Host Microbe. 2017 Mar 8;21(3):376-389.

VH1 family immunoglobulin repertoire sequencing after allogeneic hematopoietic stem cell transplantation. Sethi MK, Thol F, Stadler M, Heuser M, Ganser A, Koenecke C and Pabst O. PLoS One. 2017 Jan 17;12(1):e0168096.

The third signal cytokine IL-12 rather than immune checkpoint inhibitors contribute to the functional restoration of hepatitis D virus-specific T-cells. Schirdewahn T, Grabowski J, Sekyere SO, Bremer B, Wranke A, Lunemann S, Schlaphoff V, Kirschner J, Hardtke S, Manns MP, Cornberg M, Wedemeyer H, Suneetha PV. J Infect Dis. 2017 Jan 1;215(1):139-149.

Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Sci Rep. 2016 Jan 5;6:18594. doi: 10.1038/srep18594.

Molecular Epidemiology of Mutations in Antimicrobial Resistance Loci of Pseudomonas aeruginosa Isolates from Airways of Cystic Fibrosis Patients. Greipel L, Fischer S, Klockgether J, Dorda M, Mielke S, Wiehlmann L, Cramer N, Tümmler B. 2016. Antimicrob Agents Chemother 60:6726–6734.

Hepatitis C virus infection from the perspective of heterologous immunity. Cornberg M, Wedemeyer H. Curr Opin Virol. 2016 Jan 27;16:41-48. doi: 10.1016/j.coviro.2016.01.005.

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF. Proc Natl Acad Sci U S A. 2016 Jan 25. pii: 201516812.

Different gastric microbiota compositions in two human populations with high and low gastric cancer risk in Colombia. Yang I, Woltemate S, Piazuelo MB, Bravo LE, Yepez MC, Romero-Gallo J, Delgado AG, Wilson KT, Peek RM, Correa P, Josenhans C, Fox JG, Suerbaum S. Sci Rep. 2016 Jan 5;6:18594. doi: 10.1038/srep18594.

Genome-wide Profiling Reveals Remarkable Parallels Between Insertion Site Selection Properties of the MLV Retrovirus and the piggyBac Transposon in Primary Human CD4+ T Cells. Gogol-Döring A, Ammar I, Gupta S, Bunse M, Miskey C, Chen W, Uckert W, Schulz TF, Izsvák Z, Ivics Z. Mol Ther. 2016 Jan 12. doi: 10.1038/mt.2016.11.

Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS. Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF. Proc Natl Acad Sci U S A. 2016 Jan 25. pii: 201516812.

Conserved tryptophan motifs in the  large tegument protein pUL36 are required for efficient secondary envelopment of Herpes Simplex Virus capsid. Ivanove L, Buch A, Döhner K, Pohlmann A, Binz A, Prank U, Sandbaumhüter M, Bauerfeind R, Sodeik B. 2016, J Virol 90:5368-5383. doi:10.1128/JVI.03167-15

Functional modules of sigma factor regulons guarantee adaptability and evolvability. Binder SC, Eckweiler D, Schulz S, Bielecka A, Nicolai T, Franke R, Häussler S, Meyer-Hermann M. Sci Rep. 2016 Feb 26;6:22212

In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R. Immunity. 2016 Feb 16;44(2):233-45.

ABHD5/CGI-58, the Chanarin-Dorfman Syndrome Protein, Mobilises Lipid Stores for Hepatitis C Virus Production. Vieyres G, Welsch K, Gerold G, Gentzsch J, Kahl S, Vondran F, Kaderali L, Pietschmann T. PLOS Pathogens | DOI:10.1371/journal.ppat.1005568 April 28, 2016

Chemokines and Chemokine Receptors in Lymphoid Tissue Dynamics. Schulz O, Hammerschmidt SI, Moschovakis GL, Förster R. Annu Rev Immunol. 2016 May 20;34:203-42.

Genome-wide analysis of chromosomal import patterns after natural transformation of Helicobacter pylori. Bubendorfer S, Krebes J, Yang I, Hage E, Schulz TF, Bahlawane C, Didelot X, Suerbaum S. Nat Commun. 2016 Jun 22;7:11995.

Chemokine binding proteins: An immunomodulatory strategy going viral. González-Motos V, Kropp KA, Viejo-Borbolla A. Cytokine Growth Factor Rev. 2016 Aug;30:71-80.

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy. Hengst J, Strunz B, Deterding K, Ljunggren HG, Leeansyah E, Manns MP, Cornberg M, Sandberg JK, Wedemeyer H, Björkström NK. Eur J Immunol. 2016 Sep;46(9):2204-10.

Disruption of de novo fatty acid synthesis via acetyl-CoA carboxylase 1 inhibition prevents acute graft-versus-host disease. Raha S, Raud B, Oberdörfer L, Castro CN, Schreder A, Freitag J, Longerich T, Lochner M, Sparwasser T, Berod L, Koenecke C, Prinz I. Eur J Immunol. 2016 Sep;46(9):2233-8.

Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa. Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S. Environ Microbiol. 2016 Oct;18(10):3583-3592.

The third signal cytokine IL-12 rather than immune checkpoint inhibitors contribute to the functional restoration of hepatitis D virus-specific T-cells. Schirdewahn T, Grabowski J, Sekyere SO, Bremer B, Wranke A, Lunemann S, Schlaphoff V, Kirschner J, Hardtke S, Manns MP, Cornberg M, Wedemeyer H, Suneetha PV. J Infect Dis. 2016 Oct 31. pii: jiw514.

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C. Cell Host Microbe. 2016 Oct 12;20(4):443-457.

Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T. Cell Rep. 2016 Oct 18;17(4):1113-1127.

SNP synteny analysis of Staphylococcus aureus and Pseudomonas aeruginosa population genomics. Losada PM, Tümmler B. FEMS Microbiol Lett. 2016 Oct 3. pii: fnw229

Three-base periodicity of sites of sequence variation in Pseudomonas aeruginosa and Staphylococcus aureus core genomes. Morán Losada P, Fischer S, Chouvarine P, Tümmler B. FEBS Lett. 2016 Oct;590(20):3538-3543.

cGAS-Mediated Innate Immunity Spreads Intercellularly through HIV-1 Env-Induced Membrane Fusion Sites. Xu S, Ducroux A, Ponnurangam A, Vieyres G, Franz S, Müsken M, Zillinger T, Malassa A, Ewald E, Hornung V, Barchet W, Häussler S, Pietschmann T, Goffinet C. Cell Host Microbe. 2016 Oct 12;20(4):443-457.

Key role of an ADP − ribose – dependent transcriptional regulator ofNAD metabolism for fitness and virulence of Pseudomonas aeruginosa. Okon E, Dethlefsen S, Pelnikevich A, Barneveld AV, Munder A, Tümmler B. Int J Med Microbiol. 2016 Nov 5. pii: S1438-4221(16)30271-5.

Multilocus amplicon sequencing of Pseudomonas aeruginosa cystic fibrosis airways isolates collected prior to and after early antipseudomonal chemotherapy. Fischer S, Greipel L, Klockgether J, Dorda M, Wiehlmann L, Cramer N, Tümmler B. J Cyst Fibros. 2016 Nov 8. pii: S1569-1993(16)30648-8.

Dendritic cell migration in health and disease. Worbs T, Hammerschmidt SI, Förster R. Nat Rev Immunol. 2016 Nov 28.

Proliferation status defines functional properties of endothelial cells. Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D. Cell Mol Life Sci. 2016 Nov 16.

Filtration and Normalization of Sequencing Read Data in Whole-Metagenome Shotgun Samples. Chouvarine P, Wiehlmann L, Moran Losada P, DeLuca DS, Tümmler B. PLoS ONE 2016 11(10): e0165015.

Expanding the Host Range of Hepatitis C Virus through Viral Adaptation. von Schaewen M, Dorner M, Hueging K, Foquet L, Gerges S, Hrebikova G, Heller B, Bitzegeio J, Doerrbecker J, Horwitz JA, Gerold G, Suerbaum S, Rice CM, Meuleman P, Pietschmann T, Ploss A. MBio. 2016 Nov 8;7(6). pii: e01915-16.

Inactivation of HCV and HIV by microwave: a novel approach for prevention of virus transmission among people who inject drugs. Siddharta A, Pfaender S, Malassa A, Doerrbecker J, Anggakusuma, Engelmann M, Nugraha B, Steinmann J, Todt D, Vondran FW, Mateu-Gelabert P, Goffinet C, Steinmann E. Sci Rep. 2016 Nov 18;6:36619.

Immunometabolism and autoimmunity. Freitag J, Berod L, Kamradt T, Sparwasser T. Immunol Cell Biol. 2016 Nov;94(10):925-934.

Proliferation status defines functional properties of endothelial cells. Lipps C, Badar M, Butueva M, Dubich T, Singh VV, Rau S, Weber A, Kracht M, Köster M, May T, Schulz TF, Hauser H, Wirth D. Cell Mol Life Sci. 2016 Nov 16.

The Mouse Cytomegalovirus Gene m42 Targets Surface Expression of the Protein Tyrosine Phosphatase CD45 in Infected Macrophages. Thiel N, Keyser KA, Lemmermann NA, Oduro JD, Wagner K, Elsner C, Halenius A, Lenac Roviš T, Brinkmann MM, Jonjić S, Cicin-Sain L, Messerle M. PLoS Pathog. 2016 Dec 7;12(12):e1006057.

Systematic site-directed mutagenesis of the Helicobacter pylori CagL protein of the Cag type IV secretion system identifies novel functional domains. Bönig T, Olbermann P, Bats SH, Fischer W, Josenhans C. Sci Rep. 2016 Dec 6;6:38101.

Metabolites: deciphering the molecular language between DCs and their environment. Minarrieta L, Ghorbani P, Sparwasser T, Berod L. Semin Immunopathol. 2016 Dec 5.

Direct-Acting Antiviral–Induced Hepatitis C Virus Clearance Does Not Completely Restore the Altered Cytokine and Chemokine Milieu in Patients With Chronic Hepatitis C. Hengst J, Falk CS, Schlaphoff V, Deterding K, Manns MP, Cornberg M, Wedemeyer H. J Infect Dis. 2016 Dec 15;214(12)

Interclonal gradient of virulence in the Pseudomonas aeruginosa pangenome from disease and environment. Hilker R, Munder A, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Fischer S, Peng H, Schönfelder T, Türk O, Wiehlmann L, Wölbeling F, Gulbins E, Goesmann A, Tümmler B. Environ Microbiol. 2015 Jan;17(1):29-46. doi: 10.1111/1462-2920.12606.

A heterogeneous hierarchy of co-regulatory receptors regulates exhaustion of HCV-specific CD8 T cells in patients with chronic hepatitis C. Owusu Sekyere S, Suneetha PV, Kraft AR, Zhang S, Dietz J, Sarrazin C, Manns MP, Schlaphoff V, Cornberg M, Wedemeyer H. J Hepatol. 2015 Jan;62(1):31-40. doi: 10.1016/j.jhep.2014.08.008.

Mck2-dependent infection of alveolar macrophages promotes replication of MCMV in nodular inflammatory foci of the neonatal lung. Stahl FR, Keyser KA, Heller K, Bischoff Y, Halle S, Wagner K, Messerle M, Förster R. Mucosal Immunol. 2015 Jan;8(1):57-67. doi: 10.1038/mi.2014.42.

Dendritic cell specific targeting of MyD88 signalling pathways in vivo. Arnold-Schrauf C, Berod L, Sparwasser T. Eur J Immunol. 2015 Jan;45(1):32-9. doi: 10.1002/eji.201444747. Review

The role of Kaposi sarcoma-associated herpesvirus in the pathogenesis of Kaposi sarcoma. Gramolelli S, Schulz TF. J Pathol. 2015 Jan;235(2):368-80. doi: 10.1002/path.4441. Review.

Single-cell analysis reveals heterogeneity in onset of transgene expression from synthetic tetracycline-dependent promoters. Rand U, Riedel J, Hillebrand U, Shin D, Willenberg S, Behme S, Klawonn F, Köster M, Hauser H, Wirth D. Biotechnol J. 2015 Feb;10(2):323-31. doi: 10.1002/biot.201400076.

Fatty acid metabolism in the regulation of T cell function. Lochner M, Berod L, Sparwasser T. Trends Immunol. 2015 Feb;36(2):81-91. doi: 10.1016/

Primary biliary acids inhibit hepatitis D virus (HDV) entry into human hepatoma cells expressing the sodium-taurocholate cotransporting polypeptide (NTCP). Veloso Alves Pereira I, Buchmann B, Sandmann L, Sprinzl K, Schlaphoff V, Döhner K, Vondran F, Sarrazin C, Manns MP, Pinto Marques Souza de Oliveira C, Sodeik B, Ciesek S, von Hahn T. PLoS One. 2015 Feb 3;10(2):e0117152. doi: 10.1371/journal.pone.0117152.

A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell population restricted to the CCR6⁺CD27⁻ subset. Kashani E, Föhse L, Raha S, Sandrock I, Oberdörfer L, Koenecke C, Suerbaum S, Weiss S, Prinz I. Nat Commun. 2015 Mar 13;6:6477. doi: 10.1038/ncomms7477.

Impact of the revised International Prognostic Scoring System, cytogenetics and monosomal karyotype on outcome after allogeneic stem cell transplantation for myelodysplastic syndromes and secondary acute myeloid leukemia evolving from myelodysplastic syndromes: a retrospective multicenter study of the European Society of Blood and Marrow Transplantation. Koenecke C, Göhring G, de Wreede LC, van Biezen A, Scheid C, Volin L, Maertens J, Finke J, Schaap N, Robin M, Passweg J, Cornelissen J, Beelen D, Heuser M, de Witte T, Kröger N; MDS subcommittee of the Chronic Malignancies Working Party of the EBMT. Haematologica. 2015 Mar;100(3):400-8. doi: 10.3324/haematol.2014.116715.

Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells. Grabski E, Wappler I, Pfaender S, Steinmann E, Haid S, Dzionek A, Pietschmann T, Kalinke U. J Virol. 2015 Mar;89(6):3200-8. doi: 10.1128/JVI.03229-14.

Elucidation of sigma factor-associated networks in Pseudomonas aeruginosa reveals a modular architecture with limited and function-specific crosstalk. Schulz S, Eckweiler D, Bielecka A, Nicolai T, Franke R, Dötsch A, Hornischer K, Bruchmann S, Düvel J, Häussler S. PLoS Pathog. 2015 Mar 17;11(3):e1004744. doi: 10.1371/journal.ppat.1004744

Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition. Blanka A, Düvel J, Dötsch A, Klinkert B, Abraham WR, Kaever V, Ritter C, Narberhaus F, Häussler S. Sci Signal. 2015 Apr 14;8(372):ra36. doi: 10.1126/scisignal.2005943.

The 3D structure of Kaposi sarcoma herpesvirus LANA C-terminal domain bound to DNA. Hellert J, Weidner-Glunde M, Krausze J, Lünsdorf H, Ritter C, Schulz TF, Lührs T. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6694-9. doi: 10.1073/pnas.1421804112.

Generation of high-titre virus stocks using BrK.219, a B-cell line infected stably with recombinant Kaposi’s sarcoma-associated herpesvirus. Kati S, Hage E, Mynarek M, Ganzenmueller T, Indenbirken D, Grundhoff A, Schulz TF. J Virol Methods. 2015 Jun 1;217:79-86. doi: 10.1016/j.jviromet.2015.02.022.

Type I Interferon Elevates Co-Regulatory Receptor Expression on CMV- and EBV-Specific CD8 T Cells in Chronic Hepatitis C. Owusu Sekyere S, Suneetha PV, Hardtke S, Falk CS, Hengst J, Manns MP, Cornberg M, Wedemeyer H, Schlaphoff V. Front Immunol. 2015 Jun 10;6:270. doi: 10.3389/fimmu.2015.00270

The Pseudomonas aeruginosa Transcriptional Landscape Is Shaped by Environmental Heterogeneity and Genetic Variation. Dötsch A, Schniederjans M, Khaledi A, Hornischer K, Schulz S, Bielecka A, Eckweiler D, Pohl S, Häussler S. MBio. 2015 Jun 30;6(4):e00749. doi: 10.1128/mBio.00749-15.

Genetic Diversity Underlying the Envelope Glycoproteins of Hepatitis C Virus: Structural and Functional Consequences and the Implications for Vaccine Design. Tarr AW, Khera T, Hueging K, Sheldon J, Steinmann E, Pietschmann T, Brown RJ. Viruses. 2015 Jul 17;7(7):3995-4046. doi: 10.3390/v7072809. Review

Several Human Liver Cell Expressed Apolipoproteins Complement HCV Virus Production with Varying Efficacy Conferring Differential Specific Infectivity to Released Viruses. Hueging K, Weller R, Doepke M, Vieyres G, Todt D, Wölk B, Vondran FW, Geffers R, Lauber C, Kaderali L, Penin F, Pietschmann T. PLoS One. 2015 Jul 30;10(7):e0134529. doi: 10.1371/journal.pone.0134529.

Cyclophilin polymorphism and virus infection. von Hahn T, Ciesek S. Curr Opin Virol. 2015 Oct;14:47-9. doi: 10.1016/j.coviro.2015.07.012. Epub 2015 Aug 13. Review.

Foxp3+ T cells expressing RORγt represent a stable regulatory T-cell effector lineage with enhanced suppressive capacity during intestinal inflammation. Yang BH, Hagemann S, Mamareli P, Lauer U, Hoffmann U, Beckstette M, Föhse L, Prinz I, Pezoldt J, Suerbaum S, Sparwasser T, Hamann A, Floess S, Huehn J, Lochner M. Mucosal Immunol. 2015 Aug 26. doi: 10.1038/mi.2015.74.

Quantitative Proteomics Identifies Serum Response Factor Binding Protein 1 as a Host Factor for Hepatitis C Virus Entry. Gerold G, Meissner F, Bruening J, Welsch K, Perin PM, Baumert TF, Vondran FW, Kaderali L, Marcotrigiano J, Khan AG, Mann M, Rice CM, Pietschmann T. Cell Rep. 2015 Aug 4;12(5):864-78. doi: 10.1016/j.celrep.2015.06.063.

Targeting a host-cell entry factor barricades antiviral-resistant HCV variants from on-therapy breakthrough in human-liver mice. Vercauteren K, Brown RJ, Mesalam AA, Doerrbecker J, Bhuju S, Geffers R, Van Den Eede N, McClure CP, Troise F, Verhoye L, Baumert T, Farhoudi A, Cortese R, Ball JK, Leroux-Roels G, Pietschmann T, Nicosia A, Meuleman P. Gut. 2015 Aug 25. pii: gutjnl-2014-309045. doi: 10.1136/gutjnl-2014-309045.

Application of Synthetic Peptide Arrays To Uncover Cyclic Di-GMP Binding Motifs. Düvel J, Bense S, Möller S, Bertinetti D, Schwede F, Morr M, Eckweiler D, Genieser HG, Jänsch L, Herberg FW, Frank R, Häussler S. J Bacteriol. 2015 Aug 31;198(1):138-46. doi: 10.1128/JB.00377-15.

Frequency, Private Specificity, and Cross-Reactivity of Preexisting Hepatitis C Virus (HCV)-Specific CD8+ T Cells in HCV-Seronegative Individuals: Implications for Vaccine Responses. Zhang S, Bakshi RK, Suneetha PV, Fytili P, Antunes DA, Vieira GF, Jacobs R, Klade CS, Manns MP, Kraft AR, Wedemeyer H, Schlaphoff V, Cornberg M. J Virol. 2015 Aug;89(16):8304-17. doi: 10.1128/JVI.00539-15.

Decoding protein networks during virus entry by quantitative proteomics. Gerold G, Bruening J, Pietschmann T. Virus Res. 2015 Sep 10. pii: S0168-1702(15)30061-7. doi: 10.1016/j.virusres.2015.09.006.

Interferon-inducible cholesterol-25-hydroxylase restricts hepatitis C virus replication through blockage of membranous web formation. Anggakusuma, Romero-Brey I, Berger C, Colpitts CC, Boldanova T, Engelmann M, Todt D, Perin PM, Behrendt P, Vondran FW, Xu S, Goffinet C, Schang LM, Heim MH, Bartenschlager R, Pietschmann T, Steinmann E. Hepatology. 2015 Sep;62(3):702-14. doi: 10.1002/hep.27913.

Transcriptome analysis reveals a classical interferon signature induced by IFNλ4 in human primary cells. Lauber C, Vieyres G, Terczyńska-Dyla E, Anggakusuma, Dijkman R, Gad HH, Akhtar H, Geffers R, Vondran FW, Thiel V, Kaderali L, Pietschmann T, Hartmann R. Genes Immun. 2015 Sep;16(6):414-21. doi: 10.1038/gene.2015.23.

Acetate Dissimilation and Assimilation in Mycobacterium tuberculosis Depend on Carbon Availability. Rücker N, Billig S, Bücker R, Jahn D, Wittmann C, Bange FC. J Bacteriol. 2015 Oct;197(19):3182-90. doi: 10.1128/JB.00259-15.

Type I Interferon Released by Myeloid Dendritic Cells Reversibly Impairs Cytomegalovirus Replication by Inhibiting Immediate Early Gene Expression. Holzki JK, Dağ F, Dekhtiarenko I, Rand U, Casalegno-Garduño R, Trittel S, May T, Riese P, Čičin-Šain L. J Virol. 2015 Oct;89(19):9886-95. doi: 10.1128/JVI.01459-15.

γδ T cells come to stay: Innate skin memory in the Aldara model. Prinz I, Sandrock I. Eur J Immunol. 2015 Nov;45(11):2994-7. doi: 10.1002/eji.201546033.

MicroRNA-181a/b-1 Is Not Required for Innate γδ NKT Effector Cell Development. Sandrock I, Ziętara N, Łyszkiewicz M, Oberdörfer L, Witzlau K, Krueger A, Prinz I. PLoS One. 2015 Dec 16;10(12):e0145010. doi: 10.1371/journal.pone.0145010.

Differential Effects of Gut-Homing Molecules CC Chemokine Receptor 9 and Integrin-β7 during Acute Graft-versus-Host Disease of the Liver. Schreder A, Moschovakis GL, Halle S, Schlue J, Lee CW, Schippers A, David S, Bernhardt G, Ganser A, Pabst O, Förster R, Koenecke C. Biol Blood Marrow Transplant. 2015 Dec;21(12):2069-78. doi: 10.1016/j.bbmt.2015.08.038.

Cellular Antiviral Factors that Target Particle Infectivity of HIV-1. Goffinet C. Curr HIV Res. 2015 Dec 16. [Epub ahead of print] Review.

Microbe-associated immunomodulatory metabolites: Influence on T cell fate and function. Castro CN, Freitag J, Berod L, Lochner M, Sparwasser T. Mol Immunol. 2015 Dec;68(2 Pt C):575-84. doi: 10.1016/j.molimm.2015.07.025.

Habitat-associated skew of clone abundance in the Pseudomonas aeruginosa population. Wiehlmann L, Cramer N, Tümmler B. Environ Microbiol Rep. 2015 Dec;7(6):955-60. doi: 10.1111/1758-2229.12340.

Intraclonal genome diversity of the major Pseudomonas aeruginosa clones C and PA14. Fischer S, Klockgether J, Losada PM, Chouvarine P, Cramer N, Davenport CF, Dethlefsen S, Dorda M, Goesmann A, Hilker R, Mielke S, Schönfelder T, Suerbaum S, Türk O, Woltemate S, Wiehlmann L, Tümmler B. Environ Microbiol Rep. 2015 Dec 28. doi: 10.1111/1758-2229.12372.

Identification of the alternative sigma factor SigX regulon and its implications for Pseudomonas aeruginosa pathogenicity. Blanka A, Schulz S, Eckweiler D, Franke R, Bielecka A, Nicolai T, Casilag F, Düvel J, Abraham WR, Kaever V, Häussler S. J Bacteriol. 2014 Jan;196(2):345-56. doi: 10.1128/JB.01034-13. Epub 2013 Nov 1.

Bridging the species divide: transgenic mice humanized for type-I interferon response. Harari D, Abramovich R, Zozulya A, Smith P, Pouly S, Köster M, Hauser H, Schreiber G. PLoS One. 2014 Jan 9;9(1):e84259. doi: 10.1371/journal.pone.0084259. eCollection 2014.

Impact of single nucleotide polymorphisms in the essential HCV entry factor CD81 on HCV infectivity and neutralization. Deest M, Westhaus S, Steinmann E, Manns MP, von Hahn T, Ciesek S. Antiviral Res. 2014 Jan;101:37-44. doi: 10.1016/j.antiviral.2013.10.018. Epub 2013 Nov 7.

The complex methylome of the human gastric pathogen Helicobacter pylori. Krebes J, Morgan RD, Bunk B, Spröer C, Luong K, Parusel R, Anton BP, König C, Josenhans C, Overmann J, Roberts RJ, Korlach J, Suerbaum S. Nucleic Acids Res. 2014 Feb;42(4):2415-32. doi: 10.1093/nar/gkt1201. Epub 2013 Dec 2.

Advances in understanding Pseudomonas. Tümmler B, Wiehlmann L, Klockgether J, Cramer N. F1000Prime Rep. 2014 Feb 3;6:9. doi: 10.12703/P6-9. eCollection 2014.

Dendritic cells coordinate innate immunity via MyD88 signaling to control Listeria monocytogenes infection. Arnold-Schrauf C, Dudek M, Dielmann A, Pace L, Swallow M, Kruse F, Kühl AA, Holzmann B, Berod L, Sparwasser T. Cell Rep. 2014 Feb 27;6(4):698-708. doi: 10.1016/j.celrep.2014.01.023. Epub 2014 Feb 13.

Apolipoprotein E codetermines tissue tropism of hepatitis C virus and is crucial for viral cell-to-cell transmission by contributing to a postenvelopment step of assembly. Hueging K, Doepke M, Vieyres G, Bankwitz D, Frentzen A, Doerrbecker J, Gumz F, Haid S, Wölk B, Kaderali L, Pietschmann T. J Virol. 2014 Feb;88(3):1433-46. doi: 10.1128/JVI.01815-13. Epub 2013 Oct 30.

Reversible silencing of cytomegalovirus genomes by type I interferon governs virus latency. Dağ F, Dölken L, Holzki J, Drabig A, Weingärtner A, Schwerk J, Lienenklaus S, Conte I, Geffers R, Davenport C, Rand U, Köster M, Weiß S, Adler B, Wirth D, Messerle M, Hauser H, Cičin-Šain L. PLoS Pathog. 2014 Feb 20;10(2):e1003962. doi: 10.1371/journal.ppat.1003962. eCollection 2014.

Interferon regulatory factor-1 protects from fatal neurotropic infection with vesicular stomatitis virus by specific inhibition of viral replication in neurons. Nair S, Michaelsen-Preusse K, Finsterbusch K, Stegemann-Koniszewski S, Bruder D, Grashoff M, Korte M, Köster M, Kalinke U, Hauser H, Kröger A. PLoS Pathog. 2014 Mar 27;10(3):e1003999. doi: 10.1371/journal.ppat.1003999. eCollection 2014.

IL-17-induced CXCL12 recruits B cells and induces follicle formation in BALT in the absence of differentiated FDCs. Fleige H, Ravens S, Moschovakis GL, Bölter J, Willenzon S, Sutter G, Häussler S, Kalinke U, Prinz I, Förster R. J Exp Med. 2014 Apr 7;211(4):643-51. doi: 10.1084/jem.20131737. Epub 2014 Mar 24.

MyD88 signalling in myeloid cells is sufficient to prevent chronic mycobacterial infection. Berod L, Stüve P, Swallow M, Arnold-Schrauf C, Kruse F, Gentilini MV, Freitag J, Holzmann B, Sparwasser T. Eur J Immunol. 2014 May;44(5):1399-409. doi: 10.1002/eji.201344039. Epub 2014 Feb 13.

The extensive set of accessory Pseudomonas aeruginosa genomic components. Pohl S, Klockgether J, Eckweiler D, Khaledi A, Schniederjans M, Chouvarine P, Tümmler B, Häussler S. FEMS Microbiol Lett. 2014 Jul;356(2):235-41. doi: 10.1111/1574-6968.12445.

Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Anggakusuma, Colpitts CC, Schang LM, Rachmawati H, Frentzen A, Pfaender S, Behrendt P, Brown RJ, Bankwitz D, Steinmann J, Ott M, Meuleman P, Rice CM, Ploss A, Pietschmann T, Steinmann E. Gut. 2014 Jul;63(7):1137-49.

Rapid rebound of the Treg compartment in DEREG mice limits the impact of Treg depletion on mycobacterial burden, but prevents autoimmunity. Berod L, Stüve P, Varela F, Behrends J, Swallow M, Kruse F, Krull F, Ghorbani P, Mayer CT, Hölscher C, Sparwasser T. PLoS One. 2014 Jul 22;9(7):e102804. doi: 10.1371/journal.pone.0102804.

The gammaherpesviruses Kaposi’s sarcoma-associated herpesvirus and murine gammaherpesvirus 68 modulate the Toll-like receptor-induced proinflammatory cytokine response. Bussey KA, Reimer E, Todt H, Denker B, Gallo A, Konrad A, Ottinger M, Adler H, Stürzl M, Brune W, Brinkmann MM. J Virol. 2014 Aug;88(16):9245-59. doi: 10.1128/JVI.00841-14.

Mouse cytomegalovirus infection overrules T regulatory cell suppression on natural killer cells. Lindenberg M, Solmaz G, Puttur F, Sparwasser T. Virol J. 2014 Aug 9;11:145. doi: 10.1186/1743-422X-11-145.

Age-dependent enterocyte invasion and microcolony formation by Salmonella. Zhang K, Dupont A, Torow N, Gohde F, Leschner S, Lienenklaus S, Weiss S, Brinkmann MM, Kühnel M, Hensel M, Fulde M, Hornef MW. PLoS Pathog. 2014 Sep 11;10(9):e1004385. doi: 10.1371/journal.ppat.1004385.

Pathogenesis of Helicobacter pylori infection. Helicobacter. de Bernard M, Josenhans C. 2014 Sep;19 Suppl 1:11-8. doi: 10.1111/hel.12160. Review.

In sero veritas: what serum markers teach us about HCV infection of primary human hepatocytes. Pietschmann T. Gut. 2014 Sep;63(9):1375-7. doi: 10.1136/gutjnl-2013-306111. Commentary

Few Foxp3⁺ regulatory T cells are sufficient to protect adult mice from lethal autoimmunity. Mayer CT, Ghorbani P, Kühl AA, Stüve P, Hegemann M, Berod L, Gershwin ME, Sparwasser T. Eur J Immunol. 2014 Oct;44(10):2990-3002. doi: 10.1002/eji.201344315. Epub 2014 Aug 11.

Antigen targeting to dendritic cells combined with transient regulatory T cell inhibition results in long-term tumor regression. Unger WW, Mayer CT, Engels S, Hesse C, Perdicchio M, Puttur F, Streng-Ouwehand I, Litjens M, Kalay H, Berod L, Sparwasser T, van Kooyk Y. Oncoimmunology. 2014 Oct 31;4(8):e970462. eCollection 2015.

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T. Nat Med. 2014 Nov;20(11):1327-33. doi: 10.1038/nm.3704. Epub 2014 Oct 5.

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow. Mayer CT, Ghorbani P, Nandan A, Dudek M, Arnold-Schrauf C, Hesse C, Berod L, Stüve P, Puttur F, Merad M, Sparwasser T. Blood. 2014 Nov 13;124(20):3081-91. doi: 10.1182/blood-2013-12-545772.

Herpes simplex virus internalization into epithelial cells requires Na+/H+ exchangers and p21-activated kinases but neither clathrin- nor caveolin-mediated endocytosis. Devadas D, Koithan T, Diestel R, Prank U, Sodeik B, Döhner K. J Virol. 2014 Nov;88(22):13378-95. doi: 10.1128/JVI.03631-13.

Targeting of viral capsids to nuclear pores in a cell-free reconstitution system. Anderson F, Savulescu AF, Rudolph K, Schipke J, Cohen I, Ibiricu I, Rotem A, Grünewald K, Sodeik B, Harel A. Traffic. 2014 Nov;15(11):1266-81. doi: 10.1111/tra.12209. E

Bidirectional genomic exchange between Helicobacter pylori strains from a family in Coventry, United Kingdom. Krebes J, Didelot X, Kennemann L, Suerbaum S. Int J Med Microbiol. 2014 Nov;304(8):1135-46.

Successful anti-scavenger receptor class B type I (SR-BI) monoclonal antibody therapy in humanized mice after challenge with HCV variants with in vitro resistance to SR-BI-targeting agents. Vercauteren K, Van Den Eede N, Mesalam AA, Belouzard S, Catanese MT, Bankwitz D, Wong-Staal F, Cortese R, Dubuisson J, Rice CM, Pietschmann T, Leroux-Roels G, Nicosia A, Meuleman P. Hepatology. 2014 Nov;60(5):1508-18. doi: 10.1002/hep.27196.

Role of hypervariable region 1 for the interplay of hepatitis C virus with entry factors and lipoproteins. Bankwitz D, Vieyres G, Hueging K, Bitzegeio J, Doepke M, Chhatwal P, Haid S, Catanese MT, Zeisel MB, Nicosia A, Baumert TF, Kaderali L, Pietschmann T. J Virol. 2014 Nov;88(21):12644-55. doi: 10.1128/JVI.01145-14.

A human adenovirus species B subtype 21a associated with severe pneumonia. Hage E, Huzly D, Ganzenmueller T, Beck R, Schulz TF, Heim A. J Infect. 2014 Nov;69(5):490-9. doi: 10.1016/j.jinf.2014.06.015.

Dynamics of Lewis b binding and sequence variation of the babA adhesin gene during chronic Helicobacter pylori infection in humans. Nell S, Kennemann L, Schwarz S, Josenhans C, Suerbaum S. MBio. 2014 Dec 16;5(6). pii: e02281-14. doi: 10.1128/mBio.02281-14.

Cell culture systems for hepatitis C virus. Steinmann E, Pietschmann T. Curr Top Microbiol Immunol. 2013;369:17-48. doi: 10.1007/978-3-642-27340-7_2.

Advances in computational analysis of metagenome sequences. Davenport CF, Tümmler B. Environ Microbiol. 2013 Jan;15(1):1-5. doi: 10.1111/j.1462-2920.2012.02843.x. Epub 2012 Aug 8.

Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence. Klockgether J, Miethke N, Kubesch P, Bohn YS, Brockhausen I, Cramer N, Eberl L, Greipel J, Herrmann C, Herrmann S, Horatzek S, Lingner M, Luciano L, Salunkhe P, Schomburg D, Wehsling M, Wiehlmann L, Davenport CF, Tümmler B. Environ Microbiol. 2013 Jan;15(1):191-210. doi: 10.1111/j.1462-2920.2012.02842.x. Epub 2012 Aug 8.

Cytosolic herpes simplex virus capsids not only require binding inner tegument protein pUL36 but also pUL37 for active transport prior to secondary envelopment. Sandbaumhüter M, Döhner K, Schipke J, Binz A, Pohlmann A, Sodeik B, Bauerfeind R. Cell Microbiol. 2013 Feb;15(2):248-69. doi: 10.1111/cmi.12075. Epub 2012 Dec 20.

Ex vivo transcriptional profiling reveals a common set of genes important for the adaptation of Pseudomonas aeruginosa to chronically infected host sites. Bielecki P, Komor U, Bielecka A, Müsken M, Puchałka J, Pletz MW, Ballmann M, Martins dos Santos VA, Weiss S, Häussler S. Environ Microbiol. 2013 Feb;15(2):570-87. doi: 10.1111/1462-2920.12024. Epub 2012 Nov 12.

Entry and replication of recombinant hepatitis C viruses in cell culture. Vieyres G, Pietschmann T. Methods. 2013 Feb;59(2):233-48. doi: 10.1016/j.ymeth.2012.09.005. Epub 2012 Sep 23.

The human cytomegalovirus UL51 protein is essential for viral genome cleavage-packaging and interacts with the terminase subunits pUL56 and pUL89. Borst EM, Kleine-Albers J, Gabaev I, Babic M, Wagner K, Binz A, Degenhardt I, Kalesse M, Jonjic S, Bauerfeind R, Messerle M. J Virol. 2013 Feb;87(3):1720-32. doi: 10.1128/JVI.01955-12. Epub 2012 Nov 21.

Priming of CD8+ T cells against cytomegalovirus-encoded antigens is dominated by cross-presentation. Busche A, Jirmo AC, Welten SP, Zischke J, Noack J, Constabel H, Gatzke AK, Keyser KA, Arens R, Behrens GM, Messerle M. J Immunol. 2013 Mar 15;190(6):2767-77. doi: 10.4049/jimmunol.1200966. Epub 2013 Feb 6.

Evaluating a ligation-mediated PCR and pyrosequencing method for the detection of clonal contribution in polyclonal retrovirally transduced samples. Brugman MH, Suerth JD, Rothe M, Suerbaum S, Schambach A, Modlich U, Kustikova O, Baum C. Hum Gene Ther Methods. 2013 Apr;24(2):68-79. doi: 10.1089/hgtb.2012.175. Epub 2013 Mar 14.

Characterization of the inhibition of hepatitis C virus entry by in vitro-generated and patient-derived oxidized low-density lipoprotein. Westhaus S, Bankwitz D, Ernst S, Rohrmann K, Wappler I, Agné C, Luchtefeld M, Schieffer B, Sarrazin C, Manns MP, Pietschmann T, Ciesek S, von Hahn T. Hepatology. 2013 May;57(5):1716-24. doi: 10.1002/hep.26190. Epub 2013 Feb 15.

Hepatitis C Virus p7 is Critical for Capsid Assembly and Envelopment. Gentzsch J, Brohm C, Steinmann E, Friesland M, Menzel N, Vieyres G, Perin PM, Frentzen A, Kaderali L, Pietschmann T. PLoS Pathog. 2013;9(5):e1003355. doi: 10.1371/journal.ppat.1003355. Epub 2013 May 2.

A new reporter mouse cytomegalovirus reveals maintained immediate-early gene expression but poor virus replication in cycling liver sinusoidal endothelial cells. Dag F, Weingärtner A, Butueva M, Conte I, Holzki J, May T, Adler B, Wirth D, Cicin-Sain L. Virol J. 2013 Jun 17;10:197. doi: 10.1186/1743-422X-10-197.

Intraclonal genome diversity of Pseudomonas aeruginosa clones CHA and TB. Bezuidt OK, Klockgether J, Elsen S, Attree I, Davenport CF, Tümmler B. BMC Genomics. 2013 Jun 22;14:416. doi: 10.1186/1471-2164-14-416.

Activation of the B cell antigen receptor triggers reactivation of latent Kaposi’s sarcoma-associated herpesvirus in B cells. Kati S, Tsao EH, Günther T, Weidner-Glunde M, Rothämel T, Grundhoff A, Kellam P, Schulz TF. J Virol. 2013 Jul;87(14):8004-16. doi: 10.1128/JVI.00506-13. Epub 2013 May 15.

Generation of mouse small intestinal epithelial cell lines that allow the analysis of specific innate immune functions. Schwerk J, Köster M, Hauser H, Rohde M, Fulde M, Hornef MW, May T. PLoS One. 2013 Aug 5;8(8):e72700. doi: 10.1371/journal.pone.0072700. Print 2013.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T. PLoS Pathog. 2013;9(9):e1003648. doi: 10.1371/journal.ppat.1003648. Epub 2013 Sep 26.

Survival in hostile territory: the microbiota of the stomach. Yang I, Nell S, Suerbaum S. FEMS Microbiol Rev. 2013 Sep;37(5):736-61. doi: 10.1111/1574-6976.12027. Epub 2013 Jul 22.

Recent acquisition of Helicobacter pylori by Baka pygmies. Nell S, Eibach D, Montano V, Maady A, Nkwescheu A, Siri J, Elamin WF, Falush D, Linz B, Achtman M, Moodley Y, Suerbaum S. PLoS Genet. 2013;9(9):e1003775. doi: 10.1371/journal.pgen.1003775. Epub 2013 Sep 19.

Absence of Siglec-H in MCMV infection elevates interferon alpha production but does not enhance viral clearance. Puttur F, Arnold-Schrauf C, Lahl K, Solmaz G, Lindenberg M, Mayer CT, Gohmert M, Swallow M, van Helt C, Schmitt H, Nitschke L, Lambrecht BN, Lang R, Messerle M, Sparwasser T. PLoS Pathog. 2013;9(9):e1003648. doi: 10.1371/journal.ppat.1003648. Epub 2013 Sep 26.

Role of energy sensor TlpD of Helicobacter pylori in gerbil colonization and genome analyses after adaptation in the gerbil. Behrens W, Schweinitzer T, Bal J, Dorsch M, Bleich A, Kops F, Brenneke B, Didelot X, Suerbaum S, Josenhans C. Infect Immun. 2013 Oct;81(10):3534-51. doi: 10.1128/IAI.00750-13. Epub 2013 Jul 8.

In vivo targeting of human DC-SIGN drastically enhances CD8⁺ T-cell-mediated protective immunity. Hesse C, Ginter W, Förg T, Mayer CT, Baru AM, Arnold-Schrauf C, Unger WW, Kalay H, van Kooyk Y, Berod L, Sparwasser T. Eur J Immunol. 2013 Oct;43(10):2543-53. doi: 10.1002/eji.201343429. Epub 2013 Jul 22.

A structural basis for BRD2/4-mediated host chromatin interaction and oligomer assembly of Kaposi sarcoma-associated herpesvirus and murine gammaherpesvirus LANA proteins. Hellert J, Weidner-Glunde M, Krausze J, Richter U, Adler H, Fedorov R, Pietrek M, Rückert J, Ritter C, Schulz TF, Lührs T. PLoS Pathog. 2013;9(10):e1003640. doi: 10.1371/journal.ppat.1003640. Epub 2013 Oct 17.

Nodular inflammatory foci are sites of T cell priming and control of murine cytomegalovirus infection in the neonatal lung. Stahl FR, Heller K, Halle S, Keyser KA, Busche A, Marquardt A, Wagner K, Boelter J, Bischoff Y, Kremmer E, Arens R, Messerle M, Förster R. PLoS Pathog. 2013;9(12):e1003828. doi: 10.1371/journal.ppat.1003828. Epub 2013 Dec 12.

Bromo- and extraterminal domain chromatin regulators serve as cofactors for murine leukemia virus integration. Gupta SS, Maetzig T, Maertens GN, Sharif A, Rothe M, Weidner-Glunde M, Galla M, Schambach A, Cherepanov P, Schulz TF. J Virol. 2013 Dec;87(23):12721-36. doi: 10.1128/JVI.01942-13. Epub 2013 Sep 18.

Age, microbiota, and T cells shape diverse individual IgA repertoires in the intestine. Lindner C, Wahl B, Föhse L, Suerbaum S, Macpherson AJ, Prinz I, Pabst O. J Exp Med. 2012 Feb 13;209(2):365-77. doi: 10.1084/jem.20111980. Epub 2012 Jan 16.

A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa. Düvel J, Bertinetti D, Möller S, Schwede F, Morr M, Wissing J, Radamm L, Zimmermann B, Genieser HG, Jänsch L, Herberg FW, Häussler S. J Microbiol Methods. 2012 Feb;88(2):229-36. doi: 10.1016/j.mimet.2011.11.015. Epub 2011 Dec 8.

A role for the internal repeat of the Kaposi’s sarcoma-associated herpesvirus latent nuclear antigen in the persistence of an episomal viral genome. Alkharsah KR, Schulz TF. J Virol. 2012 Feb;86(3):1883-7. doi: 10.1128/JVI.06029-11. Epub 2011 Nov 16.

Recruitment of the tumour suppressor protein p73 by Kaposi Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Santag S, Jäger W, Karsten CB, Kati S, Pietrek M, Steinemann D, Sarek G, Ojala PM, Schulz TF. Oncogene, 2012, 1-10; doi:10.1038/onc.2012.385

Regulatory T cells selectively preserve immune privilege of self-antigens during viral central nervous system infection. Cervantes-Barragán L, Firner S, Bechmann I, Waisman A, Lahl K, Sparwasser T, Thiel V, Ludewig B. J Immunol. 2012 Apr 15;188(8):3678-85. doi: 10.4049/jimmunol.1102422. Epub 2012 Mar 9.

Bile acids specifically increase hepatitis C virus RNA-replication. Chhatwal P, Bankwitz D, Gentzsch J, Frentzen A, Schult P, Lohmann V, Pietschmann T. PLoS One. 2012;7(4):e36029. doi: 10.1371/journal.pone.0036029. Epub 2012 Apr 25.

The nucleotide excision repair (NER) system of Helicobacter pylori: role in mutation prevention and chromosomal import patterns after natural transformation. Moccia C, Krebes J, Kulick S, Didelot X, Kraft C, Bahlawane C, Suerbaum S. BMC Microbiol. 2012 May 6;12:67. doi: 10.1186/1471-2180-12-67.

Age of the association between Helicobacter pylori and man. Moodley Y, Linz B, Bond RP, Nieuwoudt M, Soodyall H, Schlebusch CM, Bernhöft S, Hale J, Suerbaum S, Mugisha L, van der Merwe SW, Achtman M. PLoS Pathog. 2012;8(5):e1002693. doi: 10.1371/journal.ppat.1002693. Epub 2012 May 10.

Multi-layered stochasticity and paracrine signal propagation shape the type-I interferon response. Rand U, Rinas M, Schwerk J, Nöhren G, Linnes M, Kröger A, Flossdorf M, Kály-Kullai K, Hauser H, Höfer T, Köster M. Mol Syst Biol. 2012 May 22;8:584. doi: 10.1038/msb.2012.17.

The ubiquitin-specific protease USP7 modulates the replication of Kaposi’s sarcoma-associated herpesvirus latent episomal DNA. Jäger W, Santag S, Weidner-Glunde M, Gellermann E, Kati S, Pietrek M, Viejo-Borbolla A, Schulz TF. J Virol. 2012 Jun;86(12):6745-57. doi: 10.1128/JVI.06840-11. Epub 2012 Apr 18.

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity. Mayer CT, Berod L, Sparwasser T. Front Immunol. 2012 Jul 3;3:183. doi: 10.3389/fimmu.2012.00183. eCollection 2012.

Genome sequence of Helicobacter pylori hpEurope strain N6. Behrens W, Bönig T, Suerbaum S, Josenhans C. J Bacteriol. 2012 Jul;194(14):3725-6. doi: 10.1128/JB.00386-12.

MAP-kinase regulated cytosolic phospholipase A2 activity is essential for production of infectious hepatitis C virus particles. Menzel N, Fischl W, Hueging K, Bankwitz D, Frentzen A, Haid S, Gentzsch J, Kaderali L, Bartenschlager R, Pietschmann T. PLoS Pathog. 2012;8(7):e1002829. doi: 10.1371/journal.ppat.1002829. Epub 2012 Jul 26.

Improper tagging of the non-essential small capsid protein VP26 impairs nuclear capsid egress of herpes simplex virus. Nagel CH, Döhner K, Binz A, Bauerfeind R, Sodeik B. PLoS One. 2012;7(8):e44177. doi: 10.1371/journal.pone.0044177. Epub 2012 Aug 31.

Genometa–a fast and accurate classifier for short metagenomic shotgun reads. Davenport CF, Neugebauer J, Beckmann N, Friedrich B, Kameri B, Kokott S, Paetow M, Siekmann B, Wieding-Drewes M, Wienhöfer M, Wolf S, Tümmler B, Ahlers V, Sprengel F. PLoS One. 2012;7(8):e41224. doi: 10.1371/journal.pone.0041224. Epub 2012 Aug 21.

Biofilm formation by Pseudomonas aeruginosa in solid murine tumors – a novel model system. Komor U, Bielecki P, Loessner H, Rohde M, Wolf K, Westphal K, Weiss S, Häussler S. Microbes Infect. 2012 Sep;14(11):951-8. doi: 10.1016/j.micinf.2012.04.002. Epub 2012 Apr 13.

Mutation in elongation factor G confers resistance to the antibiotic argyrin in the opportunistic pathogen Pseudomonas aeruginosa. Bielecki P, Lukat P, Hüsecken K, Dötsch A, Steinmetz H, Hartmann RW, Müller R, Häussler S. Chembiochem. 2012 Nov 5;13(16):2339-45. doi: 10.1002/cbic.201200479. Epub 2012 Sep 25.

Molecular epidemiology of chronic Pseudomonas aeruginosa airway infections in cystic fibrosis. Cramer N, Wiehlmann L, Ciofu O, Tamm S, Høiby N, Tümmler B. PLoS One. 2012;7(11):e50731. doi: 10.1371/journal.pone.0050731. Epub 2012 Nov 28.

In vivo sequence variation in HopZ, a phase-variable outer membrane protein of Helicobacter pylori. Kennemann L, Brenneke B, Andres S, Engstrand L, Meyer TF, Aebischer T, Josenhans C, Suerbaum S. Infect Immun. 2012 Dec;80(12):4364-73. doi: 10.1128/IAI.00977-12. Epub 2012 Oct 1.

Lack of commensal flora in Helicobacter pylori-infected INS-GAS mice reduces gastritis and delays intraepithelial neoplasia. Lofgren JL, Whary MT, Ge Z, Muthupalani S, Taylor NS, Mobley M, Potter A, Varro A, Eibach D, Suerbaum S, Wang TC, Fox JG. Gastroenterology. 2011 Jan;140(1):210-20. doi: 10.1053/j.gastro.2010.09.048. Epub 2010 Oct 13.

The Pseudomonas aeruginosa chemotaxis methyltransferase CheR1 impacts on bacterial surface sampling. Schmidt J, Müsken M, Becker T, Magnowska Z, Bertinetti D, Möller S, Zimmermann B, Herberg FW, Jänsch L, Häussler S. PLoS One. 2011 Mar 22;6(3):e18184. doi: 10.1371/journal.pone.0018184.

Helicobacter pylori genome evolution during human infection. Kennemann L, Didelot X, Aebischer T, Kuhn S, Drescher B, Droege M, Reinhardt R, Correa P, Meyer TF, Josenhans C, Falush D, Suerbaum S. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):5033-8. doi: 10.1073/pnas.1018444108. Epub 2011 Mar 7.

Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53. Coombs N, Sompallae R, Olbermann P, Gastaldello S, Göppel D, Masucci MG, Josenhans C. Int J Med Microbiol. 2011 Mar;301(3):213-24. doi: 10.1016/j.ijmm.2010.09.004. Epub 2010 Dec 4.

Dual function of the NK cell receptor 2B4 (CD244) in the regulation of HCV-specific CD8+ T cells. Schlaphoff V, Lunemann S, Suneetha PV, Jaroszewicz J, Grabowski J, Dietz J, Helfritz F, Bektas H, Sarrazin C, Manns MP, Cornberg M, Wedemeyer H. PLoS Pathog. 2011 May;7(5):e1002045. doi: 10.1371/journal.ppat.1002045. Epub 2011 May 19.

Pseudomonas aeruginosa Genomic Structure and Diversity. Klockgether J, Cramer N, Wiehlmann L, Davenport CF, Tümmler B. Front Microbiol. 2011 Jul 13;2:150. doi: 10.3389/fmicb.2011.00150. eCollection 2011.

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